Vitamin D metabolism in preeclampsia
Irina E. Zazerskaya (RU), Ekaterina S. Shelepova (RU), Elena L. Khazova (RU)
[Zazerskaya] Federal North-West Medical Research Centre, [Shelepova] Federal Almazov North-West Medical Research Centre, [Khazova] Federal Almazov North-West Medical Research Centre
Vitamin D may be a possible risk factoe for the development of preeclampsia Objective: to estimate 25-hydrocholexycalciferol level in women of reproductive age with normal pregnancy and with preeclampsia Patients: 110 pregnant women (20-40 years old): main group - pregnant women with preeclampsia (n=56) (mean age 30,6±0,52 years) and controls (n=54) – women with physiologica pregnancy (mean age 29,4±0,59 years). Interventions: venous blood sample at 3rd trimester of pregnancy Main Outcome Measure(s): Clinical features were summarized. Serum levels of 25-ОН-D were measured. Results: Frequency of vitamin D deficiency in main group 69,6% (n=39), in control group- not found. Frequency of vitamin D insufficiency in main group 21,5% (n=12), in group of comparison-18,5% (n=10). Frequency of normal vitamin D level in main group was 8,9% (n=5),in group of comparison - 81,5% (n=44). Differences between main group and group of comparison were significant (P<0,0001). Conclusions: This study has shown that vitamin D saturation in women with preeclampsia is significantly lower than in normal pregnancy. In patients with preeclampsia low serum vitamin D level is found 5 times more often (<30 ng/ml), that is why we suggest that vitamin D level (insufficiency and deficiency) could be a risk factor for the development of preeclampsia