Clinical-economic effectiveness the different methods of uterine fibroids treatment
Ainur Tuletova (KZ), Aikerm Doschanova (KZ), Galym Schegenov (KZ)
[Tuletova] Medical University Astana, [Doschanova] Medical University Astana, [Schegenov] Medical University Astana
Actuality: Now it's necessary to make a clinical-economic analysis of the effectiveness of different methods treatment. Aim: To determine the clinical-economic effectiveness of treatment of uterine fibroids. Materials: The study included 40 patients admitted to the emergency hospital with bleeding of uterine fibroids. All patients were divided according to treatment: 1group-15 patients-hysterectomy; 2group-10 patients -one dose of triptorelin 11.25 mg; 3 - 15 patients-ulipristal acetate 5 mg continuously for 3 months. Results: In the first group all patients got - amenorrhea. The unsatisfactory evaluation is associated with the removal of the organ, and the following psychological problems. In the second group the control of bleeding was achieved after 25-30-th days of injection, amenorrhea was achieved in 60% of patients. Dissatisfaction was in 30% of patients due to hot flashes from mild to severe. In the third group the control of bleeding was achieved on the first 5 days, and amenorrhea occurred on the 7-10th days of treatment at 80% patients. Dissatisfaction with the treatment was due side effects: constant headaches and mild hot flashes -1, mastalgia -1, pruritus of the skin by 1. So, the clinical effectiveness of surgery was 100%, the treatment by triptorelin – 70%, and the treatment by ulipristal acetate – 80%. Conclusions: By our research results hysterectomy was a rational method of treatment in terms of pharmacoeconomics, high efficiency and low cost. In the long term studies of the profitability of the surgery will decrease, because the price included outcomes after hysterectomy. Thus, ulipristal acetate in the treatment of symptomatic uterine fibroids is high clinical efficacy, better tolerability, but also avoids surgical operations and increases the quality of life.