Combined nutraceutical supplementation with equol, resveratrol and quercetin during the menopausal transition: effect on the symptoms and early metabolic changes.
Carlotta Zorzi (IT), Inbal Amar (IT), Carolina Bottoni (IT), Clelia Cipolla (IT), Giorgia Dinoi (IT), Antonio Lanzone (IT), Giovanni Scambia (IT), Paola Villa (IT)
[zorzi] University of Sacred Heart Roma, [Amar] University of Sacred Heart Roma, [Bottoni] University of Sacred Heart Roma, [Cipolla] University of Sacred Heart Roma, [Dinoi] University of Sacred Heart Roma, [Lanzone] University of Sacred Heart Roma, [Scambia] University of Sacred Heart Roma, [Villa] University of Sacred Heart Roma
Context: New treatment for menopausal transition. Objective: To assess the efficacy of a combined nutraceutical supplementation on the perimenopausal symptoms and early metabolic alterations. Methods: It is a prospective observational study. The study took place at the Department of Obstetrics and Gynecology service for menopause disorders. Patients: Sixty-four women in menopausal transition, who attended our service having menopausal symptoms. Interventions: Thirty-two women enrolled in the study group were prescribed one daily combined nutraceutical tablet for 6 months. Thirty-two aged matched women consisted the control group. Main outcome measures: Perimenopausal symptoms’ intensity was assessed by the modified Kuppermann index at enrollment and at 3 and 6 months of treatment. At the baseline and at the end of the study, patients underwent a clinical evaluation, a pelvic ultrasound and blood samples analysis. Results: In the nutraceutical supplemented group, a significant reduction in menopausal symptoms is demonstrated by Kuppermann index, after 3 and 6-months of supplementation (p<0.01 and p<0.001 respectively). In comparison with basal values, a significant improvement was shown in particular for hot flashes (p<0.001), insomnia (p<0.01) fatigue (p<0.01) and irritability (p<0.01.) Metabolic parameters did not show a significant change in the nutraceutical supplemented group. In control group, total Cholesterol level showed a significant increase (p<0.05). Conclusion: Combined nutraceutical supplementation provides an effective and safe solution for early symptoms occurring during menopausal transition.