Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study
Leila Nazari (IR), Saghar Salehpour (IR), Sedighe Hoseini (IR), Shahrzad Zadehmodarres (IR), Ladan Ajori (IR)
[Nazari] Shahid Beheshti University of Medical Sciences, [Salehpour] Shahid Beheshti University of Medical Sciences, [Hoseini] Shahid Beheshti University of Medical Sciences, [Zadehmodarres] Shahid Beheshti University of Medical Sciences, [Ajori] Shahid Beheshti University of Medical Sciences
Contex: Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. Objective: This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients. Methods: a pilot study Patients: Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study. Intervention: Intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer. Main Outcome Measure: serum β-HCG two weeks after embryo transfer Results: Eighteen participants were pregnant with one early miscarriage and one molar pregnancy. Sixteen clinical pregnancies were recorded and their pregnancies are ongoing. Conclusion: According to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in RIF patients.