Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism
Sameh Saleh (EG), Ahmed Salem (EG), Ihab Kamel (EG), Laila Rashed (EG)
[Saleh] Cairo University, [Salem] Cairo University, [Kamel] Cairo University, [Rashed] Cairo University
Objectives: Premature ejaculation (PE) is a common ejaculatory complaint. Two survey studies involving five nations revealed that 2.5% of men had an intravaginal ejaculation latency time of <1 min and 6% of <2 min. Recently, it was postulated that men with lifelong PE might result from a combination of polymorphisms of the serotonergic transporter and receptors, and other neurotransmitters and/or receptors. Methods: 60 patients were recruited and divided into 2 equal groups. One group was given paroxetine daily for 30 days and the other was given placebo for 30 days then after 2 weeks of wash out period cross over was done. Five ml was withdrawn from the patients and controls to determine serotonin transporter gene polymorphism. Main outcome measures: The majority of the patients were SS and SL genotypes. Paroxetine showed statistically significant response versus placebo. Conclusion: Our findings augment the significant effect of paroxetine in delaying ejaculation in the responders (P < 0.001). Meanwhile, the findings do not suggest a positive association between such response and serotonin transporter gene promoter polymorphism. International Journal of Impotence Research advance online publication, 29 September 2016; doi:10.1038/ijir.2016.36